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Node.js, a transformative force in web development, relies on mastering key JavaScript concepts. Closures enable state maintenance in asynchronous operations, prototypes form the backbone of object-oriented programming, and modules organize code for scalability. Effective error handling, currying for functional programming, and the power of 'apply', 'call', and 'bind' optimize Node.js applications. Memoization enhances performance, while Immediately Invoked Function Expressions (IIFE) and advanced argument features offer flexibility. This guide empowers Node.js developers to create robust, efficient, and future-proof applications.

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